Differential requirement of neutralizing antibodies and t cells on protective immunity to sars-cov-2 variants of concern

HIGHLIGHTS

• who: Patrick O. Azevedo from the The aim of our study was to evaluate the immunogenicity and efficacy of a DNA-based , vaccine against original and variants of SARS-Co, in disease models (K18-h, and hamsters)For this purpose, a plasmid containing full-length S gene sequence of the original SARS-Co, strain was constructed (pCTV-WS). Expression of the cloned S gene sequence in pCTV vector was confirmed by Western blot and immunofluorescence techniques. We immunized, h, transgenic mice, and hamsters with pCTV-WS and evaluated humoral and cellular immune responses by analyzing neutralizing and . . .
  

   

  

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