Differential vulnerability of locus coeruleus and dorsal raphe neurons to chronic methamphetamine-induced degeneration

HIGHLIGHTS

  • who: Steven M. Graves from the University of Wollongong, Australia have published the research: Differential vulnerability of locus coeruleus and dorsal raphe neurons to chronic methamphetamine-induced degeneration, in the Journal: (JOURNAL)
  • what: The authors demonstrate that meth increased MAOdependent mitochondrial oxidant stress in both LC and DR axons, whereas LC but not DR axons had L-type Ca2+ channeldependent mitochondrial stress. This study investigated the differential vulnerability of noradrenergic LC and serotonergic DR neurons to chronic meth-induced degeneration.
  • how: Statistical details pertaining to each experiment are provided in figure legends u03b1 . . .

     

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