Differentiation driven changes in the dynamic organization of basal transcription initiation

HIGHLIGHTS

• who: Giuseppina Giglia-Mari et al. from the IPBS, France, Department of Toxicogenetics, LUMC, Leiden, The NetherlandsFunding: This work was supported by an European Molecular Biology Organization fellowship, Erasmus University fellowship, ZonMW (Dutch Science have published the research: Differentiation Driven Changes in the Dynamic Organization of Basal Transcription Initiation, in the Journal: (JOURNAL) of October/20,/2009
• what: The authors show that, in contrast to the aforementioned paradigm, in highly differentiated postmitotic cells such as neurons, hepatocytes, and cardiac myocytes, TFIIH is effectively immobilized on the chromatin during transcription, whereas in proliferative cells, TFIIH has . . .
  

   

  

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