Digital color-coded molecular barcoding reveals dysregulation of common fus and fmrp targets in soma and neurites of als mutant motoneurons

HIGHLIGHTS

• who: Maria Giovanna Garone from the (UNIVERSITY) have published the research: Digital color-coded molecular barcoding reveals dysregulation of common FUS and FMRP targets in soma and neurites of ALS mutant motoneurons, in the Journal: (JOURNAL) of 20/09/2022
• what: The authors show that HuD overexpression, in otherwise normal MNs, produces changes strikingly similar to those observed in mutant FUS MNs on the expression of a set of genes that are: (a) involved in nervous system diseases; (b) targets of wildtype FUS in intronic regions; (c) targets of mutant FUS in the 3u2032UTR; (d . . .
  

   

  

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