Dinuclear and mononuclear metal(ii) polypyridyl complexes against drug-sensitive and drug-resistant plasmodium falciparum and their mode of action

HIGHLIGHTS

  • who: Jing Wei Lai from the Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia have published the paper: Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action, in the Journal: (JOURNAL)
  • what: Copper(II) complexes showed anti-malarial potency against both Pf3D7 and Pf5202 in sub-micromolar to micromolar range.
  • how: This section examines the inhibition of the three proteolytic sites of the 20S proteasome of the Pf3D7 and Pf5202 lysates with comparison to a known T . . .

     

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