Dioxin-elicited decrease in cobalamin redirects propionyl-coa metabolism to the β-oxidation-like pathway, resulting in acrylyl-coa conjugate buildup

HIGHLIGHTS

• who: Karina Orlowska from the Spectrometry and Metabolomics Core, Michigan State University, East Lansing, MI, USA have published the research work: Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β-oxidation-like pathway, resulting in acrylyl-CoA conjugate buildup, in the Journal: (JOURNAL) of 19/07/2022
• what: The authors propose TCDD dose dependently repressed gene_expression and enzymatic activity that redirected propionyl-CoA from the preferred Cbl-dependent carboxylation pathway to the Cbl-independent β-oxidation-like pathway resulting in the accumulation of highly reactive acrylyl-CoA, due to inhibition of ECHS1 as evident . . .
  

   

  

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