Direct binding to integrins and loss of disulfide linkage in interleukin-1β (il-1β) are involved in the agonistic action of il-1β

HIGHLIGHTS

• who: Yoko K. Takada from the (UNIVERSITY) have published the Article: Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β, in the Journal: (JOURNAL) of September/17,/2017
• what: The authors propose that the direct binding to IL-1␤ to integrins is primarily important for agonistic IL-1␤ signaling, and that the disulfide linkage indirectly affects signaling by blocking conformational changes induced by weak integrin binding to the Lys mutants. The authors studied if integrins are directly involved in the agonistic . . .
  

   

  

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