HIGHLIGHTS
- who: Ieva Drulyte from the (UNIVERSITY) have published the paper: Direct cell extraction of membrane proteins for structure-function analysis, in the Journal: Scientific Reports Scientific Reports
SUMMARY
In this proof-of-concept study, the authors present the Salipro method for the reconstitution and purification of homogenous wildtype mPANX1 and hPANX1 particles directly from cell pellets. The authors developed a PANX1 in_vitro small molecular ligand-binding assay, enabling screening compounds for this drug_target via SPR. The cryo-EM structure of mouse PANX1 was solved (3.1 Å), representing the first published structure of a . . .
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