Direct control of lysosomal catabolic activity by mtorc1 through regulation of v-atpase assembly

HIGHLIGHTS

• who: Edoardo Ratto from the (UNIVERSITY) have published the paper: Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly, in the Journal: (JOURNAL) of 12/Dec/2021
• what: The authors show that mTORC1 blocks lysosomal degradation of extracellular proteins by suppressing V-ATPase-mediated acidification of lysosomes.
• how: The authors examined whether mTORC1 inhibition regulated lysosomal protease activity. Next the authors examined the consequence of TRiC depletion for lysosomal acidification and proteolytic activity.

SUMMARY

Received Check for updates Accepted: 3 August 2022 Edoardo Ratto . . .

 



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