Direct stimulation of erbb2 highlights a novel cytostatic signaling pathway driven by the receptor thr701 phosphorylation

HIGHLIGHTS

• who: Marco Gaviraghi from the DivisionUniversity e, via Olgettina, Milan, Italy have published the paper: Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr701 phosphorylation, in the Journal: Scientific Reports Scientific Reports of 16/09/2020
• what: For AKT the authors focused on the two major phosphorylation residues phosphorylated in response to RTK activation, and necessary for AKT full enzymatic activity, i.e. u00adThr308 and u00adSer473. The authors show that, at variance to ligand activation of ERBB2-ERBB3 heterodimers by HRG or of EGFRERBB2 heterodimers by EGF, triggering both . . .
  

   

  

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