Directed evolution of the metalloproteinase inhibitor timp-1 reveals that its n- and c-terminal domains cooperate in matrix metalloproteinase recognition

HIGHLIGHTS

  • who: Maryam Raeeszadeh-Sarmazdeh from the (UNIVERSITY) have published the research: Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition, in the Journal: (JOURNAL) of April/23,/2019

SUMMARY

    Received for publication, March 6, 2019 March, and in revised form, Published, Papers in Press, April 30, 2019 April, DOI 10.1074/jbc.RA119.008321 Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix metalloproteinases (MMPs), enzymes that contribute to cancer and many inflammatory and degenerative diseases. The authors employed yeast . . .

     

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