Directly reprogrammed neurons express mapt and app splice variants pertinent to ageing and neurodegeneration

HIGHLIGHTS

• who: Mette Habekost from the Department of Biomedicine, Aarhus University, C Aarhus, Denmark have published the Article: Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration, in the Journal: (JOURNAL)
• what: The authors show that such authentically model the first crucial steps in AD pathogenesis. The authors characterise the dynamics of MAPT and APP alternative splicing during porcine and murine embryonic brain development and demonstrate that directly reprogrammed porcine neurons model agedependent and cell-type-specific patterns of MAPT and APP isoform expression allowing in_vitro modelling of ageing processes relevant . . .
  

   

  

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