Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors

HIGHLIGHTS

• who: Zhiyin Yu from the (UNIVERSITY) have published the Article: Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors, in the Journal: (JOURNAL) of 20/04/2022
• how: The gene inactivation experiments were carried out in wild-type strain L rhizosphaerae NEAU-A2.
• future: Single gene deletion experiments were then performed for knmA1 knmB1 knmB2 knmC knmE and knmF in the cluster (Supplementary Fig 41) with the altered (or absent) metabolite profile in the corresponding mutants (Fig 2) confirming that the knm BGC was required for karnamicin assembly.

SUMMARY

 



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