Discovery and mechanistic investigation of piperazinone phenylalanine derivatives with terminal indole or benzene ring as novel hiv-1 capsid modulators

HIGHLIGHTS

• who: Shujing Xu and collaborators from the School of Pharmaceutical Sciences, Shandong University, West Culture Road, Jinan, China have published the research work: Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators, in the Journal: Molecules 2022, 27, 8415. of /2022/
• what: The authors describe the design synthesis assessment of antiviral activity and mechanistic investigation of 20 derivatives with a terminal indole or Among them F2 -7f exhibited moderate anti-HIV-1 activity with an EC50 value of 5.89 u00b5M which was slightly . . .
  

   

  

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