Discovery of benzo[d]imidazole‐6‐sulfonamides as bromodomain and extra‐terminal domain (bet) inhibitors with selectivity for the first bromodomain

HIGHLIGHTS

• who: Dundee and colleagues from the University of have published the research work: Discovery of Benzo[d]imidazoleu20106u2010sulfonamides as Bromodomain and Extrau2010Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain, in the Journal: (JOURNAL)
• what: The authors designed and synthesized a series of benzimidazole-6-sulfona- mides starting from the azobenzene compounds MS436 (7 a) and MS611 (7 b) that exhibited preference for the first (BD1) over the second (BD2) BRD of family members. The authors report the design, synthesis, and biochemical evaluation of novel benzimidazole-based bromodomain BD1selective ligands.
• how: TR . . .
  

   

  

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