Discovery of cytotoxic truncated vitamin d derivatives against both bortezomib‐sensitive and bortezomib‐resistant multiple myeloma phenotypes

HIGHLIGHTS

• What: Structural simplification of natural products is a fruitful modality in drug discovery.
• Who: Radwan from the Kumamoto University Kumamoto University, Oe-honmachi, Chuo-ku, Kumamoto, Japan have published the research: Discovery of Cytotoxic Truncated Vitamin D Derivatives Against Both Bortezomib ‐ Sensitive and Resistant Multiple Myeloma Phenotypes, in the Journal: (JOURNAL)
• How: Trials for the selective monosilylation of VDF-2 using TESOTf in different conditions failed thus the authors used chlorotriethylsilane (TESCl) at -78 °C to prepare VDF-8 as described before .

SUMMARY

Cancer is the second major global . . .

 



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