Discovery of polyphenolic natural products as sars-cov-2 mpro inhibitors for covid-19

HIGHLIGHTS

• who: Nadine Kru00fcger and colleagues from the Kellnerweg, Gu00f6ttingen, Germany, Karls University Tu00fcbingen, Auf der Morgenstelle, Tu00fcbingen, Germany have published the research work: Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19, in the Journal: Pharmaceuticals 2023, 190 of /2023/
• what: The authors collected several electrophilic natural products and polyphenolic compounds and investigated them for their Mpro inhibitory activities. The model was further built using Coot and refined with XYZ (reciprocalspace), Individual B factors, TLS parameters, and occupancies implemented in the program PHENIX .
• how: Prior to examining the . . .
  

   

  

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