Disease-associated inosine misincorporation into rna hinders translation

HIGHLIGHTS

• who: RNA hinders translation and collaborators from the The Institute, University at Albany, State University of New York, Albany, NY, USA, Department of have published the paper: Disease-associated inosine misincorporation into RNA hinders translation, in the Journal: (JOURNAL)
• what: The authors demonstrate that excess ITP in the nucleotide pool during in vitro transcription results in T7 polymerase-mediated inosine misincorporation in luciferase Using this system, the authors demonstrate that titrating ITP into the NTP nucleotide pool results in a corresponding increase in misincorporated inosine within firefly and Renilla luciferase RNA, with a greater incorporation . . .
  

   

  

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