Disease-induced alterations in brain drug transporters in animal models of alzheimer’s disease

HIGHLIGHTS

  • who: Kati-Sisko Vellonen et al. from the School of Pharmacy, University of Eastern Finland, have published the article: Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease, in the Journal: (JOURNAL)
  • what: This study assessed the disease-induced changes in drug transporters in the brain capillaries of transgenic AD mice. In this study, the expression of Abc and Slc transporters relevant in pharmacokinetics and tight junction-associated proteins in the brains of three AD mouse models, APdE9, Tg2576 and APP/ PS1 were investigated. The authors focused on genes that . . .

     

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