HIGHLIGHTS
- who: Christian Osterburg from the (UNIVERSITY) have published the Article: Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree, in the Journal: (JOURNAL) of 30/03/2023
- what: The authors focus here only on p63 mutations and compare them to p53. Based on the presented data and supported by structural analysis and comparison with the wellu2010studied p53 cancer mutations the authors propose the novel classification of p63 ELA and SHFM4 mutations based on four different mechanisms of impairing DNA binding: mutations in the direct DNA contact interface, in the zinc . . .
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