Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

HIGHLIGHTS

• who: Lina Dobnikar from the Division University of London , NN, UK have published the research: Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that while the contractile VSMC signature is expressed relatively uniformly across most cells, there are pronounced differences in single-VSMC expression profiles between and within vascular beds for genes involved in cell adhesion, migration and inflammation. The authors provide experimental evidence indicating that upregulation of Sca1 is a hallmark of VSMCs undergoing phenotypic switching in_vivo . . .
  

   

  

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