Disrupted time perception underlies motivational disturbances in huntington’s disease

HIGHLIGHTS

• What: And demonstrated in human neurological disease the authors show that timing processes and motivated behaviours are fundamentally linked. This work has particularly focussed on valuation and learning about rewards and costs associated with goal directed behaviour (Le Bouc et_al, 2023; Le Heron et_al, 2018; Pessiglione et_al, 2018). Time of day was not a significant predictor and did not improve model fit so the authors report models without this covariate. The authors show that both apathy and impulsivity in HD are associated with disrupted timing judgements dependent on the nature of activity associated with the time estimation . . .
  

   

  

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