Disrupting interaction between mir-132 and mmp9 3`utr improves synaptic plasticity and memory in mice

HIGHLIGHTS

  • who: Magdalena Dziembowska from the United States McGill University, Canada have published the article: Disrupting interaction between miR-132 and Mmp9 3`UTR improves synaptic plasticity and memory in mice, in the Journal: (JOURNAL)
  • what: Using this approach, the authors demonstrated a significant increase in dendritic spine density in Mmp9 UTRmut mice compared to WT . The authors show for the first time a functional study of selected, specific miRNA-target interaction in the context of brain physiology and animal behavior. The authors show that an increased level of Mmp9 in the hippocampus resulting from lack . . .

     

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