HIGHLIGHTS
- who: Sean C. Tompkins from the University of of Medicine, Iowa City, IA, USA have published the Article: Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis, in the Journal: (JOURNAL)
- what: The authors show here, surprisingly, that mitochondrial glutamine utilization can be anticancer by competitively limiting glutathione synthesis, a key component of tumor initiation, promotion, and progression (Bansal and Simon, 2018; Harris et_al, 2015; Huang et_al, 2013; Lam et_al, 2017). The authors aimed to understand the contribution of the MPC to HCC development. The authors . . .
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