Disrupting the α-synuclein-escrt interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of parkinson⠒s disease

HIGHLIGHTS

  • who: Satra Nim from the Institute of Neurological Disorders and Stroke (NINDS) Human Gene Ontology Annotation Institute at University College London have published the article: Disrupting the u03b1-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinsonu2812s disease, in the Journal: (JOURNAL) of 21/05/2021
  • how: Source data are provided with this paper.

SUMMARY

    An AAV1/2 vector lacking the A53T a-syn open_reading_frame was used as an empty vector control (EV) for A53T a-syn experiments and an AAV1/ 2 vector expressing full-length . . .

     

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