Disruption of a conservative motif in the c-terminal loop of the kcnq1 channel causes lqt syndrome

HIGHLIGHTS

• who: Maria Karlova et al. from the Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia have published the research work: Disruption of a Conservative Motif in the C-Terminal Loop of the KCNQ1 Channel Causes LQT Syndrome, in the Journal: (JOURNAL) of 30/01/2022
• what: The aim of this study was to perform a detailed biochemical and electrophysiologin a patient with LQTS. The authors demonstrate that the exogenously expressed Kv7.1-K422E alpha subunit is sufficient for the disruption of Kv7.1 channel function , even when co-expressed with the WT form of . . .
  

   

  

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