Disruption of redox homeostasis for combinatorial drug efficacy in k-ras tumors as revealed by metabolic connectivity profiling

HIGHLIGHTS

  • who: Daniela Gaglio from the Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Segrate, MI, Italy have published the article: Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling, in the Journal: (JOURNAL)
  • what: The authors show that K-Ras-mutant lung and colon cells exhibit a distinct the latter being more dependent on respiration. To gain a more in-depth insight into the interplay between oncogenic K-Ras, tissue origin, cancer metabolic rewiring, and drug sensitivity, here, the authors provide evidence that . . .

     

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