HIGHLIGHTS
- who: Jiang Fu and collaborators from the Department of Biomedical Genetics, Center for Oral Biology, Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Rochester, New have published the article: Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration, in the Journal: (JOURNAL)
- what: The authors show that mice with neural-specific disruption of SENP2 develop movement difficulties which ultimately results in paralysis. This study shows that SENP2 controls the SUMO1mediated modification of Drp1 essential for the regulation of mitochondrial dynamics.
SUMMARY
Genetic inactivation of Senp2 reveals its . . .
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