Disruption of the interaction between mutationally activated gαq and gβγ attenuates aberrant signaling

HIGHLIGHTS

• who: Jenna L. Aumiller from the Jefferson University, Philadelphia, PA have published the article: Disruption of the interaction between mutationally activated Gu03b1q and Gu03b2u03b3 attenuates aberrant signaling, in the Journal: (JOURNAL)
• what: The authors provide evidence that disrupting the interaction between CA Gu03b1q and Gu03b2u03b3 significantly inhibits Gu03b1q-mediated activation of the MAPK and YAP/TAZ pathways. Surprisingly, the authors show differential sensitivity between Gu03b1q-QL and the Gu03b1q-QP/RC mutants in that oncogenic signaling by Gu03b1q-QP and Gu03b1qRC is more sensitive to disruption of Gu03b2u03b3 binding compared to Gu03b1q-QL. The studies . . .
  

   

  

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