HIGHLIGHTS
- who: Felix Schreibing et al. from the University of Florence, Italy have published the paper: Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling, in the Journal: (JOURNAL)
- what: The authors propose a model in which differences in the surrounding inflammatory milieu lead to crucial differences in NK-like differentiation of CD8+ effector T_cells, ultimately resulting in the appearance of NK-like CD8+ T_cell populations of different functionality and pathogenicity. The study provides insights into a poorly described CD8 + T_cell population that might be important for the antiviral response . . .
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