Dissection of the molecular circuitry controlling virulence in francisella tularensis

HIGHLIGHTS

  • who: Francisella tularensis and collaborators from the Department Duke University, Boston, Massachusetts, USA have published the paper: Dissection of the molecular circuitry controlling virulence in Francisella tularensis, in the Journal: (JOURNAL)
  • what: The authors demonstrate that which binds RNA polymerase (RNAP) also interacts with the C-terminal domain of thus anchoring the (MglA-SspA)-RNAP complex to the FPI promoter. The authors show that must be bound to ppGpp to mediate high-affinity interactions with Thus these studies unveil a novel pathway different from those described previously for regulation of transcription by ppGpp. The pivotal . . .

     

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