Dissociation of mitochondrial and ribosomal biogenesis during thallium administration in rat kidney

HIGHLIGHTS

• What: Since the authors intended to investigate the effects of the half lethal dose of Tl on the kidney and the reported LD50 of Tl for rats is 30 mg/kg, they were intraperitoneally administrated double distilled water or Tl2SO4 (30 mg/ kg), which was achieved by an administration of 1.7 mL solution per 250 g (body weight). Among them, the authors focused on Myc, since the transcriptome analysis indicated a massive increase in Myc gene_expression in response to Tl (25.32 and 20.13-fold increases 2 and 5 days after Tl administration, respectively).
 



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