(dis)solving the problem of aberrant protein states

HIGHLIGHTS

• who: from the Protein-misfolding diseases are a pernicious public health problemErrors in protein folding drive neurodegenerative disorders, such as Alzheimer`s disease (AD), Huntington`s disease (HD), Parkinson`s disease (PD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), as well as other diseases such as cancer and type , diabetes (Chuang et_al, ). Cells are equipped with mechanisms to combat aberrations in protein folding, but these systems can become overwhelmed or dysfunctional. Therefore, one strategy to confront diseases caused by pathological protein states is to bolster the innate proteostasis machinery (Mack and Shorter, ). Protein folding is a . . .
  

   

  

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