Distinct β-arrestin- and g protein-dependent pathways for parathyroid hormone receptor-stimulated erk1/2 activation*

HIGHLIGHTS

• who: Diane Gesty-Palmer from the (UNIVERSITY) have published the paper: Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation*, in the Journal: (JOURNAL) of April/21,/2006
• what: The authors show that the temporal contribution ␤-arrestin-mediated ERK1/2 activation for the PTH1R is about 35%.

SUMMARY

PTHstimulated activation of MAPK is known to have proliferative effects in kidney and bone. APRIL 21, 2006 PTH1R has been recognized as a key regulator of calcium homeostasis and bone metabolism. This differs from the reciprocal effects . . .

 



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