Distinct bacterial pathways influence the efficacy of antibiotics against mycobacterium tuberculosis

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  • who: Item Type and collaborators from the Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA have published the Article: Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis, in the Journal: (JOURNAL) of September/30,/2020
  • how: To more globally define bacterial pathways that alter drug efficacy during infection the authors designed a study to identify efficacy-altering mutations directly during infection using transposon sequencing (TNseq) in an animal model of TB. Reasoning that naturally occurring polymorphisms in these genes might be selected in the context of . . .

     

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