Distinct cellular origins and differentiation process account for distinct oncogenic and clinical behaviors of leiomyosarcomas

HIGHLIGHTS

• who: Elodie Darbo and collaborators from the Institut Bergoniu00e9, Bordeaux, France Department of Medical and Biological Sciences, University of Toulouse, Toulouse, France have published the research work: Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas, in the Journal: (JOURNAL) of 24/08/2020
• what: The authors propose that the phenotypic plasticity of vascular smooth muscle cells coupled with MYOCD/SRF pathway amplification essential for hLMS survival concomitant with PTEN absence and RB1 alteration could explain how hLMS balance this uncommon interplay between differentiation and aggressiveness. The authors focus . . .
  

   

  

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