HIGHLIGHTS
- who: Zhirong Zhang from the (UNIVERSITY) have published the paper: Distinct changes in endosomal composition promote NLRP3 inflammasome activation, in the Journal: (JOURNAL) of 15/07/2022
- what: The authors demonstrate that NLRP3 inflammasome activators primarily converge on disruption of endoplasmic_reticulum-endosome membrane contact sites (EECS). The authors propose that NLRP3 primarily senses distinct changes in the endosomal composition, including PI4P accumulation, in response to different NLRP3 activators.
- how: Data were analyzed with an unpaired two-sided t-test (b e f h). These results indicated that treatment with nigericin or CL097 blocked . . .
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