HIGHLIGHTS
- who: David Buhrke from the (UNIVERSITY) have published the article: Distinct chromophore⠍protein environments enable asymmetric activation of a bacteriophytochrome-activated diguanylate cyclase, in the Journal: (JOURNAL) of November/14,/2019
- what: By combining crystallography, hydrogen- deuterium exchange coupled to MS, and vibrational spectroscopy, the authors show here that Pfr of IsPadC is in equilibrium with an intermediate "Pfr-like" state that combines features of Pfr and Meta-R states observed in other bacteriophytochromes. The authors show that a Pfr environment can also be stabilized in the absence of the tongue region in Bphs, and . . .
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