Distinct concentration-dependent molecular pathways regulate bone cell responses to cobalt and chromium exposure from joint replacement prostheses

HIGHLIGHTS

  • who: Karan M. Shah and collaborators from the The University of, a Glossop Rd, HQ, UK have published the research work: Distinct Concentration-Dependent Molecular Pathways Regulate Bone Cell Responses to Cobalt and Chromium Exposure from Joint Replacement Prostheses, in the Journal: (JOURNAL) of 14/05/2021
  • what: The authors use whole-genome microarrays to comprehensively assess gene expression in primary human osteoblasts osteoclast precursors and mature resorbing osteoclasts following exposure to clinically relevant circulating versus local periprosthetic tissue concentrations of Co2+ and Cr3+ ions and CoCr nanopArticles. The study provides a molecular basis for . . .

     

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