HIGHLIGHTS
- who: Girish R. Kale from the CNRS Northwestern University have published the research work: Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors have investigated the effect of actomyosin contractility on cell adhesion, through the analysis of the load exerted onto E-cadherin. The authors have used Vinculin as a molecular force sensor on E-cadherin complexes, whose recruitment to adhesion complexes is modulated by the contractile activity of Myosin-II and the resulting tensile forces; hence its ratio with Ecadherin . . .
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