Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells

HIGHLIGHTS

  • who: Juraj Adamik from the (UNIVERSITY) have published the article: Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells, in the Journal: (JOURNAL) of 15/Oct/2021
  • what: The authors show previously obscured coordinate activation of multiple metabolic pathways along distinct stages of monocytic DC differentiation and maturation. In agreement with previous reports20, the authors demonstrate that p-mTOR is significantly enhanced at distinct DC stages in both tolerogenic conditions while p-AMPK was not significantly altered from controls. Despite the lack of full activation of DC maturation markers in tol-DC, here . . .

     

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