Distinct overlapping functions for prickle1 and prickle2 in the polarization of the airway epithelium

HIGHLIGHTS

• who: TYPE and collaborators from the Santa Clara University, United States have published the research work: Distinct overlapping functions for Prickle1 and Prickle2 in the polarization of the airway epithelium, in the Journal: (JOURNAL)
• what: The authors show that all four Pk paralogs are expressed in the airway epithelium and display strikingly different temporal and cell-type dependent patterns of expression. Using knockout mice in a permissive, mixed genetic background, the authors show that Pk1 and Pk2 coordinately regulate ciliary planar polarization with quantitatively and qualitatively distinct roles and entirely distinct patterns of expression. By . . .
  

   

  

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