HIGHLIGHTS
- who: Wulin Tan from the (UNIVERSITY) have published the research work: Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase, in the Journal: (JOURNAL)
- what: With single-cell RNA sequencing flow cytometry and immunohistochemistry the authors demonstrate that the sciatic nerve injury induced two distinct phases of microglia proliferation in mouse spinal cord each with different gene expression profiles. The authors demonstrate that the transcription factor was transiently upregulated in spinal cord microglia after nerve injury to mediate an microglia proliferation. The authors show that cyclin dependent . . .
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