HIGHLIGHTS
- who: Lisa J. Sudmeier from the Emory University USA have published the research: Distinct phenotypic states and spatial distribution of CD8+ Tu00a0cell clonotypes in human brain metastases, in the Journal: (JOURNAL) of May/17,/2022
- what: Using spatial transcriptomics and spatial T cell receptor (TCR) sequencing the authors show these clonally unrelated phenotypically distinct CD8+ T cell populations occupy discrete niches within the brain metastasis tumor microenvironment. The authors examine the lymphocytic infiltrate of BrMs, focusing on CD8+ T_cells given their leading role in responsiveness to current immunotherapies . The authors show that human BrMs are . . .
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