Ditfpp, a phenoxyphenol, sensitizes hepatocellular carcinoma cells to c2-ceramide-induced autophagic stress by increasing oxidative stress and er stress accompanied by lamp2 hypoglycosylation

HIGHLIGHTS

• who: Chien-Chih Chiu and collaborators from the Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan have published the research: diTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C2-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation, in the Journal: (JOURNAL)
• what: The study showed that C2 -ceramide treatment caused moderate hypoglycosylation of LAMP2 (with a lower molecular weight), while the presence of diTFPP significantly increased LAMP2 hypoglycosylation without significantly affecting the protein level of LAMP2 .
• how: The protocol utilized in the study was based on . . .
  

   

  

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