Divergent metabolism between trypanosoma congolense and trypanosoma brucei results in differential sensitivity to metabolic inhibition

HIGHLIGHTS

  • who: Pieter C. Steketee and collaborators from the The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom, Glasgow Polyomics, University of Glasgow, Glasgow, United Kingdom have published the paper: Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition, in the Journal: (JOURNAL) of July/26,/2021
  • what: The authors show that unlike T. brucei where glucose leads to high levels of pyruvate excretion T. congolense metabolises glucose to other end-products namely succinate malate and acetate. The study provides a foundation of functional . . .

     

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