Diverse modes of binding in structures of leishmania major n-myristoyltransferase with selective inhibitors

HIGHLIGHTS

• who: N-myristoyltransferase and colleagues from the Structural Biology Laboratory, Department of, of York, York , DD, England, bDepartment of have published the paper: Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors, in the Journal: IUCrJ (2014). 250-260 of /2014/

SUMMARY

The principal drugs used to treat visceral leishmaniasis have been pentavalent -amino group by the -carboxylate of the C-terminal residue acting as a base (Rudnick et_al, 1991; Bhatnagar et_al, 1994). There follows stepwise release of first the free CoA and then the N-myristoylated protein . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or Email

Password

Remember me

Lost your password?

If you don't have an account, you can create one here.