Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers

HIGHLIGHTS

• who: George Spracklin from the (UNIVERSITY) have published the paper: Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers, in the Journal: (JOURNAL) of 12/04/2022
• what: The authors demonstrate that disruption of DNA methyltransferase activity greatly remodels genome compartmentalization whereby domains lose H3K9me3-HP1u03b1/u03b2 binding and acquire the neutrally interacting state while retaining late replication timing. The authors show that H3K9me3-HP1u03b1/u03b2 heterochromatin is permissive to loop extrusion by cohesin but refractory to CTCF binding. Next, the authors aimed to investigate the interaction profile acquired by disrupted domains in . . .
  

   

  

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