Dlk1 maintains adult mice long-term hscs by activating notch signaling to restrict mitochondrial metabolism

HIGHLIGHTS

  • who: Deyu Huang from the Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China have published the research work: Dlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism, in the Journal: (JOURNAL)
  • what: The study showed that played an essential role in maintaining homeostasis which is realized by governing cell cycle and restricting metabolic activity. The authors demonstrated that Dlk1 knockout in HSCs could lead to entry of quiescent HSCs into the active cell cycle (Figs 1H, 4C).
  • how: Taken together these data . . .

     

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