Dna damage and transcription stress cause atp-mediated redesign of metabolism and potentiation of anti-oxidant buffering

HIGHLIGHTS

• who: Chiara Milanese from the Erasmus University of Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, the Netherlands have published the Article: DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors provide evidence for a mechanism governing the adaptive response elicited by sustained block of transcription caused by defective DNA repair. Previous studies have already demonstrated increased ATP levels in CS primary fibroblasts;43 here, the authors show that XP/CS primary fibroblasts also exhibit reduced PFK activity . . .
  

   

  

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